Nanoparticle-mediated drug delivery may be a promising alternative to traditional chemo-therapy of high systemic toxicity. Tumor tissue architecture poses a ...

This work introduces StoMADS, a stochastic variant of the mesh adaptive direct-search (MADS) algorithm originally developed for deterministic blackbox optim...

We introduce an iterative method named BiLQ for solving general square linear systems $Ax=b$ based on the Lanczos biorthogonalization process defined by ...

We determine optimal pricing and order quantity of two substitute products in two markets, one of them is seasonal, with a decreasing market potential over...

Cities are facing severe traffic-related problems causing emission thresholds to be exceeded. All around the world, city center access restriction policies a...

In an optimization problem, multiplying an inequality constraint by a positive scalar has no effect on the domain. However, such a transformation might have...

In this paper, we compare the BFGS and the conjugate gradient (CG) methods for solving unconstrained problems with a trust-region algorithm. The main result ...

This paper presents a linear mixed-integer formulation to solve the short-term unit commitment problem. It determines the pair of maximum efficiency points o...

In e-commerce warehouses, online retailers increase their efficiency by using a mixed-shelves (or scattered storage) concept, where unit loads are purposeful...

We introduce the conditional $p$-dispersion problem (c-pDP), an incremental variant of the $p$-dispersion problem (pDP). In the c-pDP, one is given a...

Statistical image reconstruction in X-Ray computed tomography yields large-scale regularized linear least-squares problems with nonnegativity bounds, where t...

In the present paper, we prove lower and upper bounds for each of the ratios $GA/\delta$, as well as a lower bound on $GA/\sqrt{\delta}$, in terms of...

A small polygon is a polygon of unit diameter. The question of finding the largest area of small $n-$gons has been answered for some values of $n$....

Mathematical models of energy-economy-environmental systems (E3) provide a rational framework for exploring the effects of energy and climate policies and su...

The introduction of renewable energy sources (RES) changes the shape of an electricity system's supply curve. In a perfectly competitive market, this causes ...

We address a stochastic three-level lot sizing and replenishment problem with a distribution structure in a two-stage decision process. We consider one produ...

Personnel scheduling consists of determining least-cost work schedules to cover the demand of multiple jobs expressed in number of employees per job and peri...

We consider a large group of consumers who can choose between two products at each purchasing occasion. Their choice is influenced by the marketing strateg...

We present a progressive approximation algorithm for the exact solution of several classes of interdiction games in which two non-cooperative players (namely...

The performance of deep neural networks is highly sensitive to the choice of the hyperparameters that define the structure of the network and the learning pr...