Nanoparticle-mediated drug delivery may be a promising alternative to traditional chemo-therapy of high systemic toxicity. Tumor tissue architecture poses a ...

This work introduces StoMADS, a stochastic variant of the mesh adaptive direct-search (MADS) algorithm originally developed for deterministic blackbox optim...

This article discusses the precedence-constrained class sequencing problem (PCCSP). In scheduling terms, this is a one-machine scheduling problem with preced...

Dealing with demand uncertainty in multi-item lot sizing problems poses huge challenges due to the inherent complexity. The resulting stochastic formulation...

We introduce an iterative method named BiLQ for solving general square linear systems \(Ax=b\) based on the Lanczos biorthogonalization process defined by ...

We determine optimal pricing and order quantity of two substitute products in two markets, one of them is seasonal, with a decreasing market potential over...

Cities are facing severe traffic-related problems causing emission thresholds to be exceeded. All around the world, city center access restriction policies a...

In an optimization problem, multiplying an inequality constraint by a positive scalar has no effect on the domain. However, such a transformation might have...

In this paper, we compare the BFGS and the conjugate gradient (CG) methods for solving unconstrained problems with a trust-region algorithm. The main result ...

This paper presents a linear mixed-integer formulation to solve the short-term unit commitment problem. It determines the pair of maximum efficiency points o...

In e-commerce warehouses, online retailers increase their efficiency by using a mixed-shelves (or scattered storage) concept, where unit loads are purposeful...

We introduce the conditional \(p\)-dispersion problem (c-pDP), an incremental variant of the \(p\)-dispersion problem (pDP). In the c-pDP, one is given a...

Statistical image reconstruction in X-Ray computed tomography yields large-scale regularized linear least-squares problems with nonnegativity bounds, where t...

We consider the use of demand response to address phase unbalance in a distribution grid. At present this problem is addressed by modifying the topology of t...

In the present paper, we prove lower and upper bounds for each of the ratios \(GA/\delta\), as well as a lower bound on \(GA/\sqrt{\delta}\), in terms of...

A small polygon is a polygon of unit diameter. The question of finding the largest area of small \(n-\)gons has been answered for some values of \(n\)....

Mathematical models of energy-economy-environmental systems (E3) provide a rational framework for exploring the effects of energy and climate policies and su...

This paper explores the idea that two-stage worst-case regret minimization problems with either objective or right-hand side uncertainty can be reformulated ...

The introduction of renewable energy sources (RES) changes the shape of an electricity system's supply curve. In a perfectly competitive market, this causes ...

We address a stochastic three-level lot sizing and replenishment problem with a distribution structure in a two-stage decision process. We consider one produ...