Groupe d’études et de recherche en analyse des décisions

Do Complex Statistical Methods Help in Mapping and Quantitative Traits?

David O. Siegmund

For mapping quantitative trait loci (QTL), I will discuss and compare (i) standard statistical methods for genome scans and (ii) more complex methods designed to take advantage of the possibilities of gene-gene and gene-environment interactions.

Tang and Siegmund (2001) Biostatistics 2, 147-162.
Tang and Siegmund (2002) Genetic Epidemiology 22, 313-327.
Peng and Siegmund (2004). PNAS 101, 7845-7850.
Peng, Tang and Siegmund (2005) Genetic Epidemiology, 25, 173-184.